Publications

  • A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

    Katz E, Dubois-Marshall S, Sims AH, Faratian D, Smith ES, Quinn JA, Edward M, Meehan RR, Evans EE, Langdon SP, Harrison DJ

    British Journal of Cancer 103(3) 401:10 2010

  • Correcting for intra-experiment variation in Illumina BeadChip data is necessary for robust gene-expression profiles.

    Authors: Kitchen RR, Sabine VS, Sims AH, Macaskill EJ, Renshaw L, Thomas JS, Dixon JM, Bartlett JMS (2010)

    BMC Genomics 11:134 2010

  • Downregulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and is Linked to unfavorable Prognostic Features

    Lehn S, Tobin NP, Berglund P, Nilsson K, Lamb R, Sims AH, Jirström K, Härkönen P, Landberg G.

    American Journal of Pathology 177(6):2886-97

  • Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

    Taylor K, Sims AH, Liang L, Faratian D, Muir M, Walker G, Juske B, Dixon JM, Harrison D, Cameron DA, Langdon SP

    2010 Breast Cancer Research 12: R39

  • Gene Expression Profiling of response to mTor Inhibitor Everolimus in pre-operatively treated post-menopausal women with Estrogen receptor-positive breast cancer

    Sabine VS, Sims AH, Macaskill EJ, Renshaw L, Thomas JS, Dixon JM, Barlett JMS

    Breast Cancer Research and Treatment 122(2) 419:28 2010

  • Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen.

    Authors: Blance R, Sims AH, Anderson E, Howell A, Clarke RB

    Cancer Prevention Research 2: 257:264 2010

  • The embryonic transcription cofactor LBH is a direct target of the Wnt/b-catenin pathway and is associated with aggressive Estrogen-Receptor-negatie basal-type human breast cancers

    Reiger ME, Sims AH, Clarke RB, Briegel KJ

    2010 Milecular and Cellular Biology (17) 4267-4279

  • 'Bioinformatics and breast cancer: What can high-throughput genomic approaches actually tell us?'

    Authors: Sims AH (2009)

    Journal of Clinical Pathology 62: 879-885

  • Effects of dietary energy restriction in a human intervention study of breast and adipose tissue gene expression and plasma and urine metabolomics

    Authors: Ong KR, Sims AH, Harvie M, Chapman M, Dunn WB, Broadhurst D, Goodacre R, Wilson M, Thomas N, Clarke RB$, Howell A$ (2009).

    Cancer Prevention Research 2:720-731

  • Approaches towards expression profiling the response to treatment.

    Authors: Sims AH, Bartlett JM$ (2008).

    Breast Cancer Research 10(6):115

  • Integration of breast cancer gene expression datasets by removing multiplicative, systematic bias for meta-analysis and improved prediction of prognosis.

    Authors: Sims AH, Smethurst GJ, Hey Y, Okoniewski MJ, Pepper SD, Miller CJ, Clarke RB

    BMC Medical Genomics 1:42. 2008

  • Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of deletions on heterologous laccase expression.

    Authors: Wang Y, Xue W, Sims AH, Zhao C, Wang A, Tang G, Qin J, Wang H

    Fungal Genetics and Biology 45:17-27. 2008

  • Origins of breast cancer subtypes

    Authors: Sims AH, Howell A, Clarke RB (2008).

    Book Chapter: (2nd Edition) Edited by Pasqualini JR, Informa Healthcare, 2008

  • ‘The origin of estrogen receptor α-positive and α-negative breast cancer.

    Authors: Clarke RB, Sims AH, Howell A

    Advances in Experimental Medicine and Biology 617:79-86. 2008

  • Origins of breast cancer subtypes and therapeutic implications.

    Authors: Sims AH, Howell A, Clarke RB

    Nature clinical practice oncology 4:516-25. 2007

  • TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer.

    Authors: Sims AH$, Finnon P, Miller CJ, Bouffler SD, Howell A, Scott D, Clarke RB

    International journal of Radiation Biology 83:409-20, 2007

  • Effects of Oestrogen on gene expression in epithelium and stroma of normal human breast tissue.

    Authors: Wilson CL*, Sims AH*, Howell A, Miller CJ, Clarke RB

    Endocrine-related Cancer 13: 617-628, 2006

  • Exploiting the potential of genomic medicine: Is it ready for the clinic?

    Authors: Sims AH*, Ong KR*, Clarke RB, Howell

    Breast Cancer Research 8:214, 2006

  • Prediction and prevention of breast cancer – cellular and molecular interactions

    Authors: Howell A$, Sims AH, Ong KR, Harvie MN, Evans DG, Clarke RB

    Nature clinical practice oncology 2(12) 635-646, 2005

  • Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded protein response in vivo

    Authors: Sims AH, Gent ME, Lanthaler K, Dunn-Coleman NS, Oliver SG$, Robson GD

    Applied and Environmental Microbiology 71(5) 2737-47.2005