Publications

An introduction to genes, genomes and disease.

Authors: Hall, P. A., Reis-Filho, J. S., Tomlinson, I. P. & Poulsom, R.

J Pathol 220, 109-13.

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell in press.

Authors: Heidorn, S.J., Milagre, C., Whittaker, S., Nourry, A., Niculescu-Duvas, I., Dhomen, N., Hussain, J., Reis-Filho, J.S., Springer, C.J., Pritchard, C. & Marais, R.

Next Generation Sequencing

Authors: Reis Filho JS

Breast Cancer Res 2010 in press. [short communication]

Adenoid cystic carcinomas of the breast and salivary glands (or “The Strange Case of Dr. Jekyll and Mr. Hyde” of exocrine gland carcinomas).

Authors: Marchio, C., Weigelt, B. & Reis-Filho, J.S.

J Clin Pathol in press.

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

Authors: Mackay A, Tamber N, Fenwick K, Iravani M, Grigoriadis A, Dexter T, Lord C J, Reis-Filho JS, Ashworth A

Breast Cancer Res Treat 2009 epub ahead of print. [original article]

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

Authors: Natrajan R, Weigelt B, Mackay A, Geyer FC, Grigoriadis A, Tan DS, Jones C, Lord CJ, Vatcheva R, Rodriguez-Pinilla SM, Palacios J, Ashworth A, Reis-Filho JS

Breast Cancer Res Treat 2009 Epub ahead of print. [original article]

A validated gene expression profile for detecting clinical outcome in breast cancer using artificial neural networks

Authors: Lancashire LJ, Powe DG, Reis-Filho JS, Rakha E, Lemetre C, Weigelt B, Abdel-Fatah TM, Green AR, Mukta R, Blamey R, Paish EC, Rees RC, Ellis IO, Ball GR.

Breast Cancer Res Treat 2009 epub ahed of print. [original article]

Basal-like breast carcinoma: from expression profiling to routine practice

Authors: Rakha E Reis-Filho JS

Archives of Pathology and Laboratory Medicine 2009 133:860-8. [review]

CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification

Authors: Klingbeil P, Natrajan R, Everitt G, Vatcheva R, Marchio C, Palacios J, Buerger H, Reis-Filho JS, Isacke CM

Breast Cancer Res Treat 2009 epub ahead of print. [orginal article]

Complex landscapes of somatic rearrangement in human breast cancer genomes.

Authors: Stephens, P. J., McBride, D. J., Lin, M. L., Varela, I., Pleasance, E. D., Simpson, J. T., Stebbings, L. A., Leroy, C., Edkins, S., Mudie, L. J., Greenman, C. D., Jia, M., Latimer, C.,  Teague, J. W., Lau, K. W., Burton, J., Quail, M. A., Swerdlow, H., Churcher, C., Natrajan, R., Sieuwerts, A. M., Martens, J. W., Silver, D. P., Langerod, A., Russnes, H. E., Foekens, J. A., Reis-Filho, J. S., van 't Veer, L., Richardson, A. L., Borresen-Dale, A. L., Campbell, P. J., Futreal, P. A. & Stratton, M. R.

Nature 462, 1005-10.

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation

Authors: McCarthy A, Lord CJ, Savage K, Grigoriadis A, Smith DP, Weigelt B, Reis-Filho JS, Ashworth A

J Pathol 2009 219:306-16. [original article]

Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridisation and microarray-based CGH analysis

Authors: Marchiò C, Lambros MB, Gugliotta P, Di CantognoLV, Botta C, Pasini B, Tan DSP, Mackay A, Fenwick K, Tamber N, Bussolati G, Ashworth A, Reis-Filho JS, Sapino A

J Pathol 2009 219:16-24. [original article]

EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

Authors: Bax DA, Gaspar N, Little SE, Marshall L, Perryman L, Regairaz M, Viana-Pereira M, Vuononvirta R, Sharp SY, Reis-Filho JS, Stávale JN, Al-Sarraj S, Reis RM, Vassal G, Pearson AD, Hargrave D, Ellison DW, Workman P, Jones C.

Clin Cancer Res 2009 15:5753-61. [original article]

Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas

Authors: Martinho O, Longatto-Filho A, Lambros MB, Martins A, Pinheiro C, Silva A, Pardal F, Amorim J, Mackay A, Milanezi F, Tamber N, Fenwick K, Ashworth A, Reis-Filho JS, Lopes JM, Reis RM

Br J Cancer 2009 101:973-82. [original article]

Expression of hepatocyte growth factor and its receptor met in Wilms' tumors and nephrogenic rests reflects their roles in kidney development.

Authors: Vuononvirta, R., Sebire, N. J., Messahel, B., Perusinghe, N., Reis-Filho, J. S., Pritchard-Jones, K., Vujanic, G. M. & Jones, C.

Clin Cancer Res 15, 2723-30.

Expression of HGF and its receptor Met in Wilms tumours and nephrogenic rests reflects their roles in kidney development

Authors: Vuononvirta R, Sebire N, Messahel B, Perusinghe N, Reis-Filho JS, Pritchard-Jones K, Vujanic G, Jones C

Clin Cancer Res 2009 15: 2723-30. [original article]

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.

Authors: Turner, N., Pearson, A., Sharpe, R., Lambros, M., Geyer, F., Lopez-Garcia, M.A.,Natrajan, R., Marchio, C., Iorns, E., Mackay, A., Gillett, C., Grigoriadis, A., Tutt, A., Reis- Filho, J.S. & Ashworth, A.

Cancer Res in press.

Genetic Characterisation of Breast Cancer and Implications for Clinical Management

Authors: Geyer FC, Lopez-Garcia MA, Lambros MB, Reis-Filho JS

J Cell Mol Med 2009 Epub ahead of print. [review]

Genome-wide expression profiling as a clinical tool: are we there yet?

Authors: Geyer FC, Decker T, Reis-Filho JS

Pathologe 2009 30:141-6. [review]

Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (cKit, CD117) and oestrogen receptor- (ER) in response to therapeutic radiation

Authors: Westbury CB, Reis-Filho JS, Dexter T, Mahler-Araujo B, Fenwick K, Iravani M, Grigoriadis A, Parry S, Robertson D, Mackay A, Ashworth A, Yarnold JR, Isacke CM

J Pathol 2009 219:131-40. [original article]