Publications

  • CD248(+) stromal cells are associated with progressive chronic kidney disease

    Smith SW, Earley KS, Croft AP, Nwosu J, Howie AJ, Cockwell P, Isacke CM, Buckley CD, Savage CO

    Kidney Int 2011 Apr 13 [Epub ahead of print]

  • Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome

    Henry LA, Johnson DA, Sarrio D, Lee S, Quinlan PR, Crook T, Thompson AM, Reis-Filho JS, Isacke CM

    Oncogene 2011 Mar 3; 30(9) 1046-58 Epub 2010 Nov 1

  • FAK binds RET via its FERM domain priming a direct and reciprocal RET-FAK transactivation mechanism

    Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambocorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM

    J Biol Chem 2011 Mar 22 [Epub ahead of print]

  • RET in breast cancer: functional and therapeutic implications

    Morandi A, Plaza-Menacho I, Isacke CM. (2011)

    Trends Mol Med, 2011 Mar; 17(3) 149-57 Epub 2011 Jan 19

  • The stromal cell antigen CD248 (endosialin) is expressed on naive CD8(+) human T cells nad regulates proliferation

    Hardie DL, Baldwin MJ, Naylor A, Haworth OJ, Hou TZ, Lax S, Curnow SJ, Willcox N, Macfadyen J, Isacke CM, Buckley CD

    Immunology 2011 Apr 6 doi: 10.111/j.1365-2567 O3437 [Epub ahead of print]

  • A role for fibrillar collagen deposition and the collagen internalization receptor Endo180 in glioma invasion.

    Huijbers, I.J., Iravani, M., Popov, S., Robertson, D., Al-Sarraj, S., Jones, C. and Isacke, C.M. (2010)

    PLoS ONE 2010 Mar 22 5(3):e9808

  • CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification.

    Klingbeil, P., Natrajan, R., Everitt, G., Vatcheva, R., Marchio, C., Palacios, J., Buerger, H., Reis-Filho, J.S. and Isacke, C. M.

    Breast Cancer Res Treat. (2010) Feb 120(1) 95-109 Epub 2009 Apr 7)

  • Mammary ductoscopyi in the current management of breast disease

    Tang, SK., Twelves, D.J, Isacke, C.M and Gui G.P

    Surgical Endoscopy 2010 Dec 18 [Epub ahead of print]

  • Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance

    Plaza-Menacho I, Morandi A, Robertson D, Pancholi S, Drury S, Dowsett M, Martin LA, Isacke CM

    Oncogene 2010 Aug 19; 29(33) 4648-57 Epub 2010 Jun 7

  • Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance

    Plaza-Menacho, I., Morandi, A., Robertson, D., Pancholi, S., Drury, S., Dowsett, M., Martin, L.A. and Isacke CM (2010)

    Oncogene 2010 Aug 19;29(33) 4648-4657 Epub 2010 Jun 7

  • The pericyte and stromal cell marker CD248 (Endosialin) is required for efficient lymph node expansion.

    Lax, S., Hardie, D.L., Wilson, A., Douglas, M.R., Anderson, G., Huso, D., Isacke, C.M. and Buckley, C.D. (2009)

    Eur J. Immunol. 2010 Jul; 40(7) 1884-9

  • A HaemAtlas: characterising gene expression in differentiated human blood cells.

    Authors: Watkins, W.A., Gusnanto, A., de Bono, B., De, S., Miranda-Saavedra, D., Angenent, W.G.J., Attwood, A.P., Ellis, P.D., Erber, W., Foad, N.S., Garner, S.F., Jolley, J., Koch, K., Macaulay, I.C., Morley, S.L., Rendon, A., Rice, K.M., Taylor, N., Thijssen-Timmer, D.C., Tijssen, M.R., van der Schoot, C.E., Wernisch, L., Winzer, T., Dudbridge, F., Langford, C.F., Teichmann, S., Gottgens, B., Hardie, D.L., Isacke, C.M., Buckley, C.D. and Ouwehand, W.H.

    Blood (2009) (in press) Feb 19. [Epub ahead of print]

  • Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.

    Fasquelle, C., Sartelet, A., Li, W., Dive, D., Tamma N., Michaux, C., Druet T, Huijbers I., Isacke, C.M., Coppieters, W., Georges, M. and Charlier, C.

    PLOS Genetics 5 2009 Sept 5(9) e10000666 Epub 2009 Sep 25

  • Genome-wide transcriptomic profiling of microdissected human breast tissue reveals diffferential expression of KIT (c-Kit, CD117) and oestrogen receptor-a (ERa) in response to therapeutic radiation.

    Westbury, C.B., Reis-Filho, J.S., Dexter, T., Mahler-Araugo, B., Fenwick, K., Iravani, M., Grigoriadis, A., Parry, S., Robertson, D., Mackay, A., Ashworth, A., Yarnold, J.R. and Isacke, C.M. (2009)

    J. Pathology 2009 Sept 219:131-140

  • Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor, Endo 180.

    Messaritou, G., East, L., Roghi, C., Isacke, CM. and Yarwood, H. (2009)

    J Cell Sci 2009 Nov 15; 122(pt 22):4042-4048 Epub 2009 Oct 27

  • Endosialin (CD248) is a marker of tumor-associated pericytes in high grade glioma.

    Simonavicius, N., Robertson, D., Bax, D.A., Jones, C., Huijbers, I.J. and Isacke, C.M.

    Mod. Pathology (2008) 21(3):308-315 Epub 2008 Jan 11

  • Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue.

    Robertson, D, Savage K, Reis-Filho JS, Isacke CM 

    BMC Cell Biol 2008 Mar 19;9:13

  • A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer.

    Noble, J.L., Dua, R.S., Coulton, G.R., Isacke, C.M. and Gui, G.P.

    Eur J Cancer. (2007) Nov;43(16) 2315-2320 Epub 2007 Sep 27

  • A role for GDNF-induced expression by inflammatory cytokines and RET/GFRα1 receptor upregulation in breast cancer.

    Esseghir, S., Todd, S.K., Hunt, T., Poulsom, R., Plaza-Menacho, I., Reis-Filho, J.S. and Isacke, C.M.

    Cancer Res. (2007) Dec 15:67(24) 11732-11741

  • CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.

    Lax, S., Hou, T.Z., Jenkinson, E., Salmon, M., MacFadyen, J.R., Isacke, C.M., Anderson, G., Cunningham, A.F. and Buckley, C.D.

    FEBS Lett (2007) Jul 24 581 (18), 3550-3556 Epub 2007 Jul 3