Publications

CYP3A Variation, Premenopausal Estrone Levels, and Breast Cancer Risk

Johnson N, Walker K, Gibson LJ, Orr N, Folkerd E, Haynes B, Palles C, Coupland B, Schoemaker M, Jones M, Broderick P, Sawyer E, Kerin M, Tomlinson IP, Zvelebil M, Chilcott-Burns S, Tomczyk K, Simpson G, Williamson J, Hillier SG, Ross G, Houlston RS, Swerdlow A, Ashworth A, Dowsett M, Peto J, Dos Santos Silva I, Fletcher O

J Natl Cancer Inst. 2012; 104(9):657-669

Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases

Dudbridge F, Fletcher O, Walker K, Johnson N, Orr N, Dos Santos Silva I, Peto J

Cancer Epidemiol Biomarkers Prev. 2012; 21(2):262-72

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, et al

Nat Genet. 2012; 44(3):312-8

Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk

Brennan K, Garcia-Closas M, Orr N, Fletcher O, Jones M, Ashworth A, Swerdlow A, Thorne H; on behalf of KConFab Investigators, Riboli E, Vineis P, Dorronsoro M, Clavel-Chapelon F, Panico S, Onland-Moret NC, Trichopoulos D, Kaaks R, Khaw KT, Brown R, Flanagan JM

Cancer Res. 2012; 72(9):2304-2313

Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men

Orr N, Cooke R, Jones M, Fletcher O, Dudbridge F, Chilcott-Burns S, Tomczyk K, Broderick P, Houlston R, Ashworth A, Swerdlow A

PLoS Genet. 2011;7(9):e1002290

High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform

Lambros MB, Wilkerson PM, Natrajan R, Patani N, Pawar V, Vatcheva R, Mansour M, Laschet M, Oelze B, Orr N, Muller S, Reis-Filho JS

Lab Invest. 2011; 91(10):1491-501

Novel breast cancer susceptibility locus at 9q31.2: results of a genone-wide association study

Fletcher, O., Johnson, N., Orr, N., Hosking, F.J., et al

Natl Cancer Inst. 2011; 103: 425-435

Architecture of inherited susceptibility to common cancer

Fletcher, O. and Houlston, R

Nature Reviews Cancer 2010; 10: 353-361

Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls

Fletcher, O., Johnson, N., dos Santos Silva, I., Orr, N., et al

Cancer Epidemiol Biomarkers Prev. 2010; 19: 2143-51

Family history, genetic testing and clinical risk prediction: pooled analysis of CHEK2*1100delC in 1,828 bilateral breast cancers and 7030 controls

Authors: Fletcher O, Johnson N, dos Santos Silva I, Kilpivaara O, Aittomäki K, Blomqvist C, Nevanlinna H, Wasielewski M, Meijers-Heijerboer H, Broeks A, Schmidt M, Bogdanova N, Bremer M, Dörk T, Chekmariova E. V, Sokolenko A. P, Imyanitov E. N, Hamann U, Rashid MU, Brauch H, Justenhoven C, Ashworth A, Peto J.

Cancer Epidemiol Biomarkers Prev. 2010; 18: 230-234

Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Authors: Yeager M, Chatterjee N, Ciampa J, Jacobs KB, Gonzalez Bosquet J, Hayes RB, Kraft P, Wacholder S, Orr N, Berndt S, Yu K, Hutchinson A, Wang Z, Amundadottir L, Spencer Feigelson H, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Haiman CA, Henderson B, Kolonel L, Le Marchand L, Siddiq A, Riboli E, Isaacs W, Isaacs S, Wiley KE, Gronberg H, Wiklund F, Stattin P, Xu J, Zheng SL, Sun J, Vatten LJ, Hveem K, Kumle M, Tucker M, Gerhard DS, Hoover RS, Fraumeni Jr JF, Hunter DJ, Thomas G, Chanock SJ.

Nat Genet. 2009; 41(10): 1055-7

Association of genetic variants at 8q24 with breast cancer risk.

Authors: Fletcher O, Johnson N, Gibson L, Coupland B, Fraser A, Leonard A, dos Santos Silva I, Ashworth A, Houlston R, Peto J. 

Cancer Epidemiol Biomarkers Prev 2008; 17: 702-705

Common genetic variation and human disease.

Authors: Orr N, Chanock S.

Adv Genet. 2008; 62:1-32

Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.

Authors: Yeager M, Xiao N, Hayes RB, Bouffard P, Desany B, Burdett L, Orr N, Matthews C, Qi L, Crenshaw A, Markovic Z, Fredrikson KM, Jacobs KB, Amundadottir L, Jarvie TP, Hunter DJ, Hoover R, Thomas G, Harkins TT, Chanock SJ.

Hum Genet. 2008; 124(2): 161-70

Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy.

Authors: Palles C, Johnson N, Coupland B, Taylor C, Carvajal J, Holly J, Fentiman IS, dos Santos Silva I, Ashworth A, Peto J, Fletcher O.

Hum Mol Genet. 2008; 17: 1457-64

Multiple novel loci identified in a genome-wide association study of prostate cancer.

Authors: Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Spencer Feigelson H, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ.

Nat Genet. 2008; 40(3):310-5

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.

Authors: Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GC, Ziegler RG, Berg CD, Buys SS, McCarty CA, Spencer Feigelson H, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Thomas G, Chanock SJ.

Nat Genet. 2007; 39(7):870-4

Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.

Authors: Johnson, N., Fletcher, O., Palles, C., Rudd, M., Webb, E., Sellick, G., Dos Santos Silva, I., McCormack, V., Gibson, L., Fraser, A., Leonard, A., Gilham, C., Tavtigian, S.V., Ashworth, A., Houlston, R. and Peto, J.

Hum Mol Genet 2007; 16: 1051-1057

Genome-wide association study identifies novel breast cancer susceptibility loci.

Authors: Easton, D.F., Pooley, K.A. et al.

Nature 2007; 447: 1087-1093

Genome-wide association study of prostate cancer identifies a second locus at 8q24.

Authors: Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Spencer Feigelson H, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hunter DJ, Chanock SJ, Thomas G.

Nat Genet. 2007; 39(5):645-649