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Endocrinology projects

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Molecular response to estrogen deprivation

Molecular features of early acquired resistance

Acquired resistance to tamoxifen or an aromatase inhibitor in advanced breast cancer.

Clinical significance of polymorphisms in the oestrogen response mechanism.

In vitro Studies

Gene Metyhlation profiles and E-dependent gene expression

Kinase signalling and ER protein-protein interactions

Pharmacological Studies

Oestrogenic androgens and oestrogen dependent gene expression.