Publications

A cancer associated Aurora-A mutant is mislocalised and misregulated due to loss of interaction with TPX2.

Authors: Bibby R, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, Bayliss R and Linardopoulos S.

JBC 284, 33177-33184.

The Mitotic Kinase Aurora-A Suppresses Homology-Directed DNA Double Strand-Break Repair.

Authors: Sourisseau T, Maniotis M, Tang C, Lord CJ, Ashworth A and Linardopoulos S.

EMBO Mol Med. in Revision.

A regulation of NF-κB signalling via IκBα ubiquitination.

Authors: Briassouli P, Chan F, Savage K, Reis-Filho JS and Linardopoulos S. Aurora-

Cancer Res (2007) 15: 1689-1695

Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents.

Authors: Sun C., Chan F., Briassouli P., Linardopoulos S.

Biochem Biophys Res Commun. (2007) 352(1): 220-225.

Mechanism of Action of the Aurora Kinase Inhibitor CCT129202 and In vivo Quantification of Biological Activity.

Authors: Chan F, Sun C., Perumal M., Nguyen Q-D., Bavetsias V., McDonald E., Martins V., Wilsher N.E., Raynaud F.I., Valenti M, Eccles S., te Poele R., Workman P, Aboagye E.O. and Linardopoulos S.

Mol Cancer Ther (2007) 6: 3147-3157

The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I{kappa}B{alpha}.

Authors: Briassouli, P., Chan, F. and Linardopoulos, S.

Human Molecular Genetics (2006) 15(22): 3343-50

High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase.

Authors: Sun C, Newbatt Y, Douglas L, Workman P, Aherne W and Linardopoulos S.

J. Biomol. Screening (2004) 9(5):391-397

Identification of Aurora2/STK6/STK15 as a candidate low penetrance tumor susceptibility gene in mouse and man.

Authors: Ewart-Toland, A., Briassouli, P., de Koning, J.P., Mao, J-H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B.A.J., Nagase, H., Burns, J., West, S., Linardopoulos, S. and Balmain, A.

Nat Genet (2003) 34, 403-412