Publications

Immune-induced IMD cleavage, DIAP2 association, and K63-ubiquitination drives innate immune signalling in Drosophila. Mol Cell.

Authors: Paquette N., Broemer M., Aggarwal K., Husson M., Ertϋrk-Hasdemir D., Reichhart J.M., Meier P., Neal Silverman.

A tangled web of Ubiquitin chains – Breaking news in TNF-R1

Authors: Bianchi K., Meier P.

Mol Cell. 2009, Dec 11;36(5):736-42.

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death.

Authors: Orme M, Meier P.

Apoptosis. 2009 Aug;14(8):950-60.

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes.

Authors: Ertürk-Hasdemir D., Broemer M., Leulier F., Lane W.S., Paquette N., Hwang D., Kim C.H., Stöven S., Meier P.*, Silverman N.

Proc Natl Acad Sci U S A. 2009, 106(24):9779-84.

Ubiquitin-mediated regulation of apoptosis.

Authors: Broemer M, Meier P.

Trends Cell Biol. 2009, 19(3):130-40

IAPs Carry an evolutionarily conserved ubiquitin-binding domain that is indispensable for NF-kB regulation as well as cell survival and oncogenesis.

Authors: Gyrd-Hansen M.*, Darding M.*, Miasari M., Tenev T., da Fonseca P., Zvelebil M., Bujnicki J., Silke J., Santoro M.M., Lowe S, and Meier P. (*) equal contribution.

Nat Cell Biol. (11),1309-17. 2008

Inactivation of effector caspases through non-degradative polyubiquitylation.

Authors: Ditzel M.*, Broemer M.*, Tenev T., Bolduc C., Elliott R., Zvelebil M., Bergmann A. and Meier P. (*) equal contribution.

Mol Cell. (4), 540-553. 2008

PIMS modulates immune tolerance by negatively regulating the Drosophila Imd pathway.

Authors: Lhocine N.*, Ribeiro P.S.*, Buchon N., Wepf A., Wilson R., Tenev T., Lemaitre B., Gstaiger M.$, Meier P$, Leulier F$.

Cell Host & Microbes. (4), 147-158. 2008

DIAP2 functions as a ‘mechanism-based’ regulator of drICE that contributes to the caspase activity threshold in living cells.

Authors: Ribeiro P., Kuranaga E., Tenev T., Leulier, F., Miura M., and Meier P.

J Cell Biol. (7):1467-1480. 2007

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.

Authors: Ribeiro PS, Kuranaga E, Tenev T, Leulier F, Miura M, Meier P.

J Cell Biol. Dec 31;179(7):1467-80, 2007.

Lucifer’s Labyrinth – Ten Years of Pathfinding in Cell Death.

Authors: Meier P and Vousden KH.

Mol. Cell. Dec 14;28(5):746-54, 2007.

The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.

Authors: Tenev, T., Ditzel, M., Zachariou, A. and Meier, P.

Cell Death Differ 14(10):1191-201 (2007)

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

Authors: Leulier F., Ribeiro PS., Palmer E., Tenev T., Takahashi K., Robertson D., Zachariou A., Pichaud F., Ueda R. and P. Meier.

Cell Death & Diff. 1-12; 2006.

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection.

Authors: Leulier, F, Lhocine, N, Lemaitre, B and P. Meier.

Mol Cell Biol 26: 7821-31; 2006

IAPs are functionally non-equivalent and regulate effector-caspases through distinct mechanisms.

Authors: Tenev T., A. Zachariou, R. Wilson, M. Ditzel and P. Meier.

Nat Cell Biol 7(1): 70-77; 2005.

Ubiquitylation in apoptosis: DIAP’s (N-)en(d)igma.

Authors: Ditzel M. and P. Meier.

Cell Death & Diff. 12: 1208-1212; 2005.

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

Authors: Ditzel M., R. Wilson, T. Tenev, A. Zachariou, A. Paul, E. Deas and P. Meier.

Nat Cell Biol 5, 467-73; 2003.

IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding.

Authors: Zachariou, A., T. Tenev, L. Goyal, J. Agapite, H. Steller and P. Meier. 22

EMBO J (24): 6642-52; 2003.

Programmed cell death: Superman meets Dr Death.

Authors: Meier, P. and J. Silke.

Nat Cell Biol 5(12): 1035-8; 2003.

Apoptosis: More than Meets the Eye.

Authors: Ditzel M and P. Meier.

Cell 111, 465-467; 2002