Publications

Abdel-Fatah, T.M., Powe, D.G., Hodi, Z., Lee, A.H., Reis-Filho, J.S. and Ellis, I.O. High Frequency of Coexistence of Columnar Cell Lesions, Lobular Neoplasia, and Low Grade Ductal Carcinoma In Situ With Invasive Tubular Carcinoma and Invasive Lobular Carcinoma.
Am J Surg Pathol (2007) 31, 417-426.
Amary, M.F., Berisha, F., Bernardi Fdel, C., Herbert, A., James, M., Reis-Filho, J.S., Fisher, C., Nicholson, A.G., Tirabosco, R., Diss, T.C. and Flanagan, A.M. Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma.
Mod Pathol (2007) 20, 482-496.
Arriola, E., Lambros, M.B., Jones, C., Dexter, T., Mackay, A., Tan, D.S., Tamber, N., Fenwick, K., Ashworth, A., Dowsett, M. and Reis-Filho, J.S. Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Lab Invest (2007) 87, 75-83.
Arriola, E., Rodriguez-Pinilla, S.M., Lambros, M.B., Jones, R.L., James, M., Savage, K., Smith, I.E., Dowsett, M. and Reis-Filho, J.S. Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer.
Breast Cancer Res Treat. (2007)
Briassouli, P., Chan, F., Savage, K., Reis-Filho, J.S. and Linardopoulos, S. Aurora-A Regulation of Nuclear Factor-{kappa}B Signaling by Phosphorylation of I{kappa}B{alpha}.
Cancer Res (2007) 67, 1689-1695.
Di Palma, S., Lambros, M.B., Savage, K., Jones, C., Mackay, A., Dexter, T., Iravani, M., Fenwick, K., Ashworth, A. and Reis-Filho, J.S. Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.
J Clin Pathol (2007) 60, 492-499.
Elsheikh, S., Green, A.R., Aleskandarany, M.A., Grainge, M., Paish, C.E., Lambros, M.B., Reis-Filho, J.S. and Ellis, I.O. CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome.
Breast Cancer Res Treat. (2007)
Elsheikh, S.E., Green, A.R., Lambros, M.B., Turner, N.C., Grainge, M.J., Powe, D., Ellis, I.O. and Reis-Filho, J.S. FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis.
Breast Cancer Res (2007) 9, R23.
Esseghir, S., Kennedy, A., Seedhar, P., Nerurkar, A., Poulsom, R., Reis-Filho, J.S. and Isacke, C.M. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.
Clin Cancer Res (2007) 13, 3164-3173.
Fulford, L.G., Reis-Filho, J.S., Ryder, K., Jones, C., Gillett, C.E., Hanby, A., Easton, D. and Lakhani, S.R. Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival.
Breast Cancer Res (2007) 9, R4.
Gomes, A.L., Reis-Filho, J.S., Lopes, J.M., Martinho, O., Lambros, M.B., Martins, A., Schmitt, F., Pardal, F. and Reis, R.M. Molecular alterations of KIT oncogene in gliomas.
Cell Oncol (2007) 29, 399-408.
Jones, C., Rodriguez-Pinilla, M., Lambros, M., Bax, D., Messahel, B., Vujanic, G.M., Reis-Filho, J.S. and Pritchard-Jones, K. c-KIT overexpression, without gene amplification and mutation, in paediatric renal tumours.
J Clin Pathol (2007) 60, 1226-1231.
Lambros, M.B., Natrajan, R. and Reis-Filho, J.S. Chromogenic and fluorescent in situ hybridization in breast cancer.
Hum Pathol (2007) 38, 1105-1122.
Lee, A.H., Paish, E.C., Marchio, C., Sapino, A., Schmitt, F.C., Ellis, I.O. and Reis-Filho, J.S. The expression of Wilms' tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast.
Histopathology (2007) 51, 824-828.
Little, S.E., Bax, D.A., Rodriguez-Pinilla, M., Natrajan, R., Messahel, B., Pritchard-Jones, K., Vujanic, G.M., Reis-Filho, J.S. and Jones, C. Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.
Clin Cancer Res (2007) 13, 4360-4364.
McCarthy, A., Savage, K., Gabriel, A., Naceur, C., Reis-Filho, J. and Ashworth, A. A mouse model of basal-like breast carcinoma with metaplastic elements.
J Pathol (2007) 211, 389-398.
Natrajan, R., Little, S.E., Sodha, N., Reis-Filho, J.S., Mackay, A., Fenwick, K., Ashworth, A., Perlman, E.J., Dome, J.S., Grundy, P.E., Pritchard-Jones, K. and Jones, C. Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour.
J Pathol (2007) 211, 52-59.
Natrajan, R., Warren, W., Messahel, B., Reis-Filho, J.S., Brundler, M.A., Dome, J., Grundy, P., Vujanic, G., Pritchard-Jones, K. and Jones, C. Complex patterns of chromosome 9 alterations including the p16INK4A locus in Wilms tumours.
J Clin Pathol. (2007)
Natrajan, R., Williams, R.D., Grigoriadis, A., Mackay, A., Fenwick, K., Ashworth, A., Dome, J.S., Grundy, P.E., Pritchard-Jones, K. and Jones, C. Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.
Genes Chromosomes Cancer. (2007)
Pierga, J.Y., Reis-Filho, J.S., Cleator, S.J., Dexter, T., Mackay, A., Simpson, P., Fenwick, K., Iravani, M., Salter, J., Hills, M., Jones, C., Ashworth, A., Smith, I.E., Powles, T. and Dowsett, M. Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
Br J Cancer (2007) 96, 341-351.
Pinder, S.E., Provenzano, E. and Reis-Filho, J.S. Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management.
Pathology (2007) 39, 208-216.
Pinder, S.E. and Reis-Filho, J.S. Non-operative breast pathology.
J Clin Pathol (2007) 60, 1297-1299
Pinder, S.E. and Reis-Filho, J.S. Non-operative breast pathology: columnar cell lesions.
J Clin Pathol (2007) 60, 1307-1312
Rakha, E.A., Tan, D.S., Foulkes, W.D., Ellis, I.O., Tutt, A., Nielsen, T.O. and Reis-Filho, J.S. Are triple negative tumours and basal-like breast cancer synonymous?
Breast Cancer Res (2007) 9, R80.
Reis-Filho, J.S. and Pinder, S.E. Non-operative breast pathology: lobular neoplasia.
J Clin Pathol (2007) 60, 1321-1327.
Rodriguez-Pinilla, S.M., Jones, R.L., Lambros, M.B., Arriola, E., Savage, K., James, M., Pinder, S.E. and Reis-Filho, J.S. MYC amplification in breast cancer: a chromogenic in situ hybridisation study.
J Clin Pathol (2007) 60, 1017-1023.
Rodriguez-Pinilla, S.M., Sarrio, D., Moreno-Bueno, G., Rodriguez-Gil, Y., Martinez, M.A., Hernandez, L., Hardisson, D., Reis-Filho, J.S. and Palacios, J. Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer.
Mod Pathol (2007)
Savage, K., Lambros, M.B., Robertson, D., Jones, R.L., Jones, C., Mackay, A., James, M., Hornick, J.L., Pereira, E.M., Milanezi, F., Fletcher, C.D., Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Clin Cancer Res (2007) 13, 90-101.
Savage, K., Leung, S., Todd, S.K., Brown, L.A., Jones, R.L., Robertson, D., James, M., Parry, S., Rodrigues Pinilla, S.M., Huntsman, D. and Reis-Filho, J.S. Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis.
Breast Cancer Res Treat. (2007)
Svensson Mansson, S., Reis-Filho, J. and Landberg, G. Transcriptional upregulation and unmethylation of the promoter region of p16 in invasive basal cell carcinoma cells and partial co-localization with the gamma2 chain of laminin-332.
J Pathol. (2007)
Tan, D.S., Lambros, M.B., Natrajan, R. and Reis-Filho, J.S. Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research.
Lab Invest (2007) 87, 737-754.
Tan, D.S., Marchio, C., Jones, R.L., Savage, K., Smith, I.E., Dowsett, M. and Reis-Filho, J.S. Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients.
Breast Cancer Res Treat. (2007)
Thorat, M.A., Marchio, C., Morimiya, A., Savage, K., Nakshatri, H., Reis-Filho, J.S. and Badve, S. FOXA1 expression in breast cancer is associated with Luminal subtype and good prognosis.
J Clin Pathol. (2007)
Tischkowitz, M., Xia, B., Sabbaghian, N., Reis-Filho, J.S., Hamel, N., Li, G., van Beers, E.H., Li, L., Khalil, T., Quenneville, L.A., Omeroglu, A., Poll, A., Lepage, P., Wong, N., Nederlof, P.M., Ashworth, A., Tonin, P.N., Narod, S.A., Livingston, D.M. and Foulkes, W.D. Analysis of PALB2/FANCN-associated breast cancer families.
Proc Natl Acad Sci U S A (2007) 104, 6788-6793.
Turner, N.C., Reis-Filho, J.S., Russell, A.M., Springall, R.J., Ryder, K., Steele, D., Savage, K., Gillett, C.E., Schmitt, F.C., Ashworth, A. and Tutt, A.N. BRCA1 dysfunction in sporadic basal-like breast cancer.
Oncogene (2007) 26, 2126-2132.
Westbury, C.B., Pearson, A., Nerurkar, A., Reis-Filho, J.S., Steele, D., Peckitt, C., Sharp, G. and Yarnold, J.R. Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride.
Br J Radiol. (2007)
Wienke, D., Davies, G.C., Johnson, D.A., Sturge, J., Lambros, M.B., Savage, K., Elsheikh, S.E., Green, A.R., Ellis, I.O., Robertson, D., Reis-Filho, J.S. and Isacke, C.M. The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.
Cancer Res (2007) 67, 10230-10240.
Elbauomy Elsheikh S, Green AR, Lambros MB, Turner NC, Grainge MJ, Powe D, Ellis IO, Reis-Filho JS. FGFR1 amplificationin breast carcinomas:a hromogenic insitu hybridisation analysis.
Breast Cancer Res 2007; 9: R23.
Esseghir S, Todd SK, Hunt T, Poulsom R, Plaza-Menacho I, Reis-Filho JS, Isacke CM. A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR-64-alpha 1 receptor up-regulation in breast cancer.
Cancer Res 2007; 67: 11732-41.
Banerjee, S., Reis-Filho, J.S., Ashley, S., Steele, D., Ashworth, A., Lakhani, S.R. and Smith, I.E. Basal-like breast carcinomas: clinical outcome and response to chemotherapy.
J Clin Pathol (2006) 59, 729-735.
Savage, K., Lambros, M.B., Robertson, D., Jones, R.L., Jones, C., Mackay, A., James, M., Hornick, J.L., Pereira, E.M., Milanezi, F., Fletcher, C.D., Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Clin Cancer Res (2007) 13, 90-101.
Fulford, L.G., Easton, D.F., Reis-Filho, J.S., Sofronis, A., Gillett, C.E., Lakhani, S.R. and Hanby, A. Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast.
Histopathology (2006) 49, 22-34.
Di Palma, S., Lambros, M.B., Savage, K., Jones, C., Mackay, A., Dexter, T., Iravani, M., Fenwick, K., Ashworth, A. and Reis Filho, J.S. Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.
J Clin Pathol. (2006)
Grigoriadis, A., Mackay, A., Reis-Filho, J.S., Steele, D., Iseli, C., Stevenson, B., Jongeneel, C.V., Valgeirsson, H., Fenwick, K., Iravani, M., Leao, M., Simpson, A.S., Strausberg, R.L., Jat, P.J., Ashworth, A., Neville, A.M. and O'Hare M, J. Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.
Breast Cancer Res (2006) 8, R56.
Lambros, M.B., Simpson, P.T., Jones, C., Natrajan, R., Westbury, C., Steele, D., Savage, K., Mackay, A., Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Lab Invest (2006) 86, 398-408.
Little, S.E., Vuononvirta, R., Reis-Filho, J.S., Natrajan, R., Iravani, M., Fenwick, K., Mackay, A., Ashworth, A., Pritchard-Jones, K. and Jones, C. Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.
Genomics (2006) 87, 298-306.
Natrajan, R., Little, S., Sodha, N., Reis-Filho, J., Mackay, A., Fenwick, K., Ashworth, A., Perlman, E., Dome, J., Grundy, P., Pritchard-Jones, K. and Jones, C. Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour.
(2006) 211, 52-59. J Pathol
Natrajan, R., Little, S.E., Reis-Filho, J.S., Hing, L., Messahel, B., Grundy, P.E., Dome, J.S., Schneider, T., Vujanic, G.M., Pritchard-Jones, K. and Jones, C. Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors.
Clin Cancer Res (2006) 12, 7284-7293.
Pierga, J.Y., Reis-Filho, J.S., Cleator, S.J., Dexter, T., Mackay, A., Simpson, P., Fenwick, K., Iravani, M., Salter, J., Hills, M., Jones, C., Ashworth, A., Smith, I.E., Powles, T. and Dowsett, M. Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
Br J Cancer. (2006)
Natrajan, R., Reis-Filho, J.S., Little, S.E., Messahel, B., Brundler, M.A., Dome, J.S., Grundy, P.E., Vujanic, G.M., Pritchard-Jones, K. and Jones, C. Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse.
Cancer Res (2006) 66, 11148-11155.
Natrajan, R., Williams, R., Hing, S., Mackay, A., Reis-Filho, J., Fenwick, K., Iravani, M., Valgeirsson, H., Grigoriadis, A., Langford, C., Dovey, O., Gregory, S., Weber, B., Ashworth, A., Grundy, P., Pritchard-Jones, K. and Jones, C. Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.
J Pathol (2006) 210, 49-58.
Pinder, S.E. and Reis-Filho, J.S. Non Operative Breast Pathology: columnar cell lesions.
J Clin Pathol. (2006)
Reis-Filho, J.S. and Pinder, S.E. Non Operative Breast Pathology: lobular neoplasia.
J Clin Pathol. (2006)
Reis-Filho, J.S., Savage, K., Lambros, M.B., James, M., Steele, D., Jones, R.L. and Dowsett, M. . Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis.
Mod Pathol (2006) 19, 999-1009,
Reis-Filho, J.S., Milanezi, F., Steele, D., Savage, K., Simpson, P.T., Nesland, J.M., Pereira, E.M., Lakhani, S.R. and Schmitt, F.C. Metaplastic breast carcinomas are basal-like tumours.
Histopathology (2006) 49, 10-21.
Reis-Filho, J.S., Pinheiro, C., Lambros, M.B., Milanezi, F., Carvalho, S., Savage, K., Simpson, P.T., Jones, C., Swift, S., Mackay, A., Reis, R.M., Hornick, J.L., Pereira, E.M., Baltazar, F., Fletcher, C.D., Ashworth, A., Lakhani, S.R. and Schmitt, F.C. EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.
J Pathol (2006) 209, 445-453.
Reis-Filho, J.S., Simpson, P.T., Turner, N.C., Lambros, M.B., Jones, C., Mackay, A., Grigoriadis, A., Sarrio, D., Savage, K., Dexter, T., Iravani, M., Fenwick, K., Weber, B., Hardisson, D., Schmitt, F.C., Palacios, J., Lakhani, S.R. and Ashworth, A. FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas.
Clin Cancer Res (2006) 12, 6652-6662.
Reis-Filho, J.S., Steele, D., Di Palma, S., Jones, R.L., Savage, K., James, M., Milanezi, F., Schmitt, F.C. and Ashworth, A. Distribution and significance of nerve growth factor receptor (NGFR/p75(NTR)) in normal, benign and malignant breast tissue.
Mod Pathol (2006) 19, 307-319.
Rodriguez-Pinilla, S.M., Jones, R.L., Lambros, M.B., Arriola, E., Savage, K., James, M., Pinder, S.E. and Reis-Filho, J.S. MYC amplification in breast cancer: a chromogenic in situ hybridisation study.
J Clin Pathol. (2006)
Reis-Filho, J.S., Westbury, C. and Pierga, J.Y. J Clin Pathol
The impact of expression profiling on prognostic and predictive testing in breast cancer. (2006) 59, 225-231.
Turner, N.C. and Reis-Filho, J.S.
Basal-like breast cancer and the BRCA1 phenotype.
Oncogene (2006) 25, 5846-5853.
Mahler-Araujo B, Savage K, Parry S, Reis-Filho JS. Reduction of E-cadherin expression is associated with non-lobular breast
carcinomas of basal-like and triple negative phenotype.
J Clin Pathol 2007 [Epub ahead of print]
Turner, N.C., Reis-Filho, J.S., Russell, A.M., Springall, R.J., Ryder, K., Steele, D., Savage, K., Gillett, C.E., Schmitt, F.C., Ashworth, A. and Tutt, A.N. BRCA1 dysfunction in sporadic basal-like breast cancer.
Oncogene. (2006)