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Coactivator/corepressor interactions with ER in the endocrine resistant setting
Establishing the role of coactivator/corepressors associated with ER in LTED and TamR cells.
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Role of oestrogen receptor (ER) and HER-2 in the regulation of VEGF and tumour angiogenesis in endocrine resistant breast tumours
Investigating ER regulation of VEGF in an acquired endocrine resistant model.
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Transcriptional profiles of endocrine resistant cells
Establishing how other key pathways controlling cell proliferation are deregulated using microarray.
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Invasive potential of endocrine resistant cells
Focused on the invasive phenotype of these resistant cell lines and possible points for therapeutic intervention.
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Combination of signal transduction inhibitors with endocrine agents
Investigating ways to improve the efficacy of current endocrine agents as well as delaying the onset of resistance by targeting concomitantly ER and pertinent signal transduction pathways.
