Publications

Robertson, D., Savage, K., Reis-Filho, J. S. and Isacke, C. M. Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue.
BMC Cell Biol. (2008) 9:13.
Simonavicius, N., Robertson, D., Bax, D.A., Jones, C., Huijbers, I.J. and Isacke, C.M. Endosialin (CD248) is a marker of tumor-associated pericytes in high grade glioma.
Mod. Pathology (2008) 21:308-315
Virgintino, D., Errede, M., Girolamo, F., Capobianco, C., Robertson, D., Vimercati, A., Serio, G., Di Benedetto, A., Yonekawa, Y., Frei, K. and
Roncali, L. Fetal blood-brain barrier Pglycoprotein contributes to brain protection during human development.
J. Neuropathol. Exp. Neurol. [Epub ahead of print] (2007)
Esseghir, S., Todd, S.K., Hunt, T., Poulsom, R., Plaza-Menacho, I., Reis-Filho, J.S. and Isacke, C.M. A role for GDNF-induced expression by inflammatory cytokines and RET/GFRα1 receptor upregulation in breast cancer.
Cancer Res. (2007) 67: 11732-11741
Wienke, D., Davies, G.C., Johnson, D.A., Sturge, J., Lambros, M.B., Savage, K., Elsheikh, S.E., Green, A.R., Ellis, I.O., Robertson, D., Reis-Filho, J.S. and Isacke, C.M. The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.
Cancer Res (2007) 67, 10230-10240.
Esseghir, S., Kennedy, A., Seedhar, P., Nerurkar, A., Poulsom, R., Reis-Filho, J.S. and Isacke, C.M. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.
Clin Cancer Res (2007) 13, 3164-3173.
Lax, S., Hou, T.Z., Jenkinson, E., Salmon, M., MacFadyen, J.R., Isacke, C.M., Anderson, G., Cunningham, A.F. and Buckley, C.D. CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
FEBS Lett (2007) 581, 3550-3556.
Macfadyen J., Savage K., Wienke D. and Isacke C.M. Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development.
Gene Expression Patterns (2007) 7: 363-369
Noble, J.L., Dua, R.S., Coulton, G.R., Isacke, C.M. and Gui, G.P. A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer.
Eur J Cancer. (2007) 43:2315-2320
Noble, J., Dua, R.S., Locke, I., Eeles, R., Gui, G.P. and Isacke, C.M. Proteomic analysis of nipple aspirate fluid throughout the menstrual cycle in healthy pre-menopausal women.
Breast Cancer Res Treat. (2007) 104:191-196
Nolte-'t Hoen, E., Almeida, C., Cohen, N., Nedvetzki, S., Yarwood, H. and Davis, D. Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication.
Blood. (2007) 109, 670-673
Plaza-Menacho, I., Mologni, L., Sala, E., Gambacorti-Passerini, C., Magee, A.I., Links, T.P., Hofstra, R.M., Barford, D. and Isacke, C.M. Sorafenib Functions to Potently Suppress RET Tyrosine Kinase Activity by Direct Enzymatic Inhibition and Promoting RET Lysosomal Degradation Independent of Proteasomal Targeting.
J Biol Chem (2007) 282, 29230-29240.
Plaza-Menacho, I., van der Sluis, T., Hollema, H., Gimm, O., Buys, C.H., Magee, A.I., Isacke, C.M., Hofstra, R.M. and Eggen, B.J. Ras/ERK1/2-mediated STAT3 Serine 727 phosphorylation by familiar medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity and transformation.
J Biol Chem. (2007)
Savage, K., Leung, S., Todd, S.K., Brown, L.A., Jones, R.L., Robertson, D., James, M., Parry, S., Rodrigues Pinilla, S.M., Huntsman, D. and Reis-Filho, J.S. Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis.
Breast Cancer Res Treat. (2007) 110:245-256
Sleeman K.E., Kendrick H., Robertson D., Isacke C.M., Ashworth A., Smalley M.J. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
J Cell Biol. (2007) 176:19-26
Sturge, J., Todd, S.K., Kogianni, G., McCarthy, A. and Isacke, C.M. Mannose receptor regulation of macrophage cell migration.
J Leukoc Biol (2007) 82, 585-593.
Virgintino, D., Girolamo, F., Errede, M., Capobianco, C., Robertson, D., Stallcup, W.B., Perris, R. and Roncali, L. An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis.
Angiogenesis. (2007) 10, 35-45
Plaza-Menacho, I., van der Sluis, T., Hollema, H., Gimm, O., Buys, C.H., Magee, A.I., Isacke, C.M., Hofstra, R.M. and Eggen, B.J. Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
J Biol Chem (2007) 282, 6415-6424.
Westbury, C.B., Pearson, A., Nerurkar, A., Reis-Filho, J.S., Steele, D.,
Peckitt, C., Sharp, G. and Yarnold, J.R. Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride.
Br. J. Radiol. (2007) 80, 934-938.
Mason, J.C., Lidington, E.A. and Yarwood, H. Isolation and analysis of large and small vessel endothelial cells.
Methods Mol Med. (2007) 135, 305-321.
Savage, K., Lambros, M.B., Robertson, D., Jones, R.L., Jones, C., Mackay, A., James, M., Hornick, J.L., Pereira, E.M., Milanezi, F., Fletcher, C.D.,
Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Caveolin 1 is overexpressed and amplified in a subset of basal-like and
metaplastic breast carcinomas: a morphologic, ultrastructural,
immunohistochemical, and in situ hybridization analysis.
Clin Cancer Res (2007) 13, 90-101.
Honardoust H.A., Jiang G., Koivisto L., Wienke D., Isacke C.M., Larjava H., Hakkinen L. Expression of Endo180 is spatially and temporally regulated during wound healing.
Histopathology. (2006) 49:634-48
Esseghir, S., Reis-Filho, J., Kennedy, A., James, M., O'Hare, M., Jeffery, R., Poulsom, R. and Isacke, C. Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts.
J Pathol. (2006) 210: 420-430
Sturge, J., Wienke, D. and Isacke, C.M. Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly.
J Cell Biol (2006) 175: 337-347
Paraskeva PA, Ridgway PF, Olsen S, Isacke C, Peck DH, Darzi AW. A surgically induced hypoxic environment causes changes in the metastatic behaviour of tumours in vitro.
Clin Exp Metastasis (2006) 23: 149-157
Tzircotis G, Thorne RF and Isacke CM. Directional sensing of a phorbol ester gradient requires CD44 and is regulated by CD44 phosphorylation.
Oncogene (2006) 25:7401-10
Martinez-Pomares, L., Wienke, D., Stillion, R., McKenzie, E.J., Arnold, J., Harris, J., McGreal, E., Sim, R.B., Isacke, C.M. and Gordon, S. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor.
Eur J Immunol. (2006) 36:1074-1082
Dua, R.S., Isacke, C.M. and Gui, G.P.H. The intraductal approach to breast cancer biomarker discovery.
J Clin Oncol. (2006) 24: 1209-1216
Boskovic, J., Arnold, J.N., Stilion, R., Gordon, S., Sim, R.B., Rivera-Calzada, A., Wienke, D., Isacke, C.M., Martinez-Pomares, L. and Llorca, O. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor.
J Biol Chem. (2006) 281(13):8780-8787
Croft, D.R., Coleman, M.L., Li, S., Robertson, D., Sullivan, T., Stewart, C.L. and Olson, M.F. Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
J Cell Biol. (2005) 168: 245-255
Zola, H., Swart, B., Nicholson, I., Aasted, B., Bensussan, A., Boumsell, L., Buckley, C., Clark, G., Drbal, K., Engel, P., Hart, D., Horejsi, V., Isacke, C., Macardle, P., Malavasi, F., Mason, D., Olive, D., Saalmueller, A., Schlossman, S.F., Schwartz-Albiez, R., Simmons, P., Tedder, T.F., Uguccioni, M. and Warren, H. CD molecules 2005: human cell differentiation molecules.
Blood. (2005) 106: 3123-3126
Sleeman, K.E., Kendrick, H., Ashworth, A., Isacke, C.M. and Smalley, M.
J. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial and non-epithelial cells.
Breast Cancer Res. (2005) 8: R7
Dua, R.S., Gui, G.P. & Isacke, C.M. Endothelial adhesion molecules in breast cancer invasion into the vascular and lymphatic systems.
Eur J Surg Oncol. (2005) 31: 824-32.
Tzircotis, G., Thorne, R. F. & Isacke, C. M. Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44:hyaluronan binding.
J Cell Sci. (2005) 118: 5119-5128
Reis-Filho, J.S., Westbury, C. & Pierga, J-P. The impact of expression profiling on prognostic and predictive testing in breast cancer.
J Clin Pathol. (2005) 59:225-31
Westbury, C. & Yarnold, J. Can a ‘low risk’ subgroup be identified in whom radiotherapy can be safely omitted after breast conservation surgery?
The Effective Management of Breast Cancer, UK Key Advances in Clinical Practice Series. (2005)
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., Martin, N.M., Jackson, S.P., Smith, G.C., Ashworth, A. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature (2005) 434: 917-921
MacFadyen, J. R., Haworth, O., Roberston, D., Hardie, D., Webster, M. T., Morris, H. R., Panico, M., Sutton-Smith, M., Dell, A., van der Geer, P., Wienke, D., Buckley, C.D., Isacke, C.M. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium.
FEBS Lett. (2005) 579: 2569-2575.
Donovan, E., Coles, C., Westbury, C. & Yarnold, J. Breast. Radiotherapy in Practice: Volume II External Beam Radiotherapy.
Oxford University Press. (2005)
Thomas, E. K., Nakamura, M., Wienke, D., Isacke, C. M., Pozzi, A., and Liang, P. Endo180 Binds to the C-terminal Region of Type I Collagen.
J Biol Chem (2005) 280: 22596-22605