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Cell surface and secreted factors involved in breast cancer invasion and metastasis
Identifying cell surface or secreted molecules upregulated in invasive/metastatic breast cancer.
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Role of the endocytic receptor, Endo180, in cell migration and matrix remodeling
Our research is focused towards elucidating the physiological and pathophysiological role of Endo180.
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Stromal cells in disease; the role of endosialin
Using a variety of in vivo and in vitro approaches to address the functional role of endosialin, particularly in modulating tumour cell behaviour and angiogenesis.
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Regulation of CD44/ERM junctional complexes
Investigating the molecular regulation of the hyaluronan receptor CD44 and its association with ERM (ezrin, radixin, moesin) proteins in membrane:cytoskeletal junctional complexes.
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Characterisation of human breast tumour stem cells
Identifying subpopulations of primary human tumour cells with "tumour stem cell"-like properties.
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An intraductal approach to the identification of breast cancer biomarkers
Determining whether analysis of the intraductal fluid obtained by nipple aspiration can identify breast cancer biomarkers.
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Molecular mechanisms of late radiation injury in normal human breast tissue
Identifing new candidate genes involved in this pathological response to help elucidate the molecular pathogenesis of post radiation fibrosis and to provide possible molecular targets for therapy.
