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Stromal fibroblasts in breast cancer invasion
Our studies are aimed at understanding the function of cancer-associated fibroblasts in breast cancer invasion and in particular the role of stromal transmembrane receptors
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The pericyte receptor endosialin in tumour angiogenesis
Understanding the recruitment, activation and function of pericytes during tumour angiogenesis
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Recruitment and activation of mesenchymal stem cells in tumour progression and metastasis
This project aims to understand the mechanisms by which tumour cells recruit and activate stromal cells and the impact of stromal activation on tumour progression and metastasis and the response to therapies
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Tumour and metastasis suppressor genes
Identification of key tumour and metastasis suppressor genes in breast cancer
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Myoepithelial differentiation in basal-like breast tumours
The aim of this project is to assess the molecular mechanisms regulating cell fate decisions made by normal myoepithelial cells and breast cancer stem cells
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Functional and therapeutic implications of the receptor tyrosine kinase RET in breast cancer
This study is investigating the role of RET in the functional regulation of ERa and in the response and resistance to endocrine therapies
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An intraductal approach to the identification of breast cancer biomarkers
This project aims to identify biomarkers for the early diagnosis of women at high risk of breast cancer.
