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Characterisation of mammary epithelial stem cells
Identification and verification of mammary stem cells.
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Cell fate determination in the mammary epithelium
We want to understand what determines how cells progress down the stem – progenitor – differentiated cell hierarchy, and what defines a cell at each of these stages.
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HER2 and mammary stem cells
The aims of this project are to investigate the role of HER2 in the normal mammary epithelium, the relationship between HER2 status and mammary stem/progenitor cell behaviour and the origin of HER2-positive tumours.
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Characterisation of stem cell populations in tumour models and understanding the cells of origin of different breast cancer types
We are extending our analysis of cellular subpopulations in the normal mammary epithelium to examine which different cell types are present in tumours arising in genetic models of breast cancer.
