Publications
Brough, R., Wei, D., Leulier, S., Lord, C.J., Rong, Y.S. and Ashworth, A. Functional analysis of Drosophila melanogaster BRCA2 in DNA repair.
DNA Repair (Amst). (2007)
Gudmundsdottir, K., Lord, C.J. and Ashworth, A. The proteasome is involved in determining differential utilization of double-strand break repair pathways.
Oncogene. (2007)
Iorns, E., Lord, C.J., Turner, N. and Ashworth, A. Utilizing RNA interference to enhance cancer drug discovery.
Nat Rev Drug Discov (2007) 6, 556-568.
Lord, C.J. and Ashworth, A. RAD51, BRCA2 and DNA repair: a partial resolution.
Nat Struct Mol Biol, (2007) 14, 461-462.
Rayter, S., Elliott, R., Travers, J., Rowlands, M.G., Richardson, T.B., Boxall, K., Jones, K., Linardopoulos, S., Workman, P., Aherne, W., Lord, C.J. and Ashworth, A. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
Oncogene. (2007)
Takeda, S., Iwai, A., Nakashima, M., Fujikura, D., Chiba, S., Li, H.M., Uehara, J., Kawaguchi, S., Kaya, M., Nagoya, S., Wada, T., Yuan, J., Rayter, S., Ashworth, A., Reed, J.C., Yamashita, T., Uede, T. and Miyazaki, T. LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma.
Anticancer Res (2007) 27, 761-768.
Arias-Lopez, C., Lazaro-Trueba, I., Kerr, P., Lord, C.J., Dexter, T., Iravani, M., Ashworth, A. and Silva, A. p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
EMBO Rep (2006) 7, 219-224.
Balkwill, F.R., Ashworth, A., Bast, R.C., Berek, J.S., Boyd, J., Disis, M.L., Gabra, H., Gore, M.E., Hamilton, T.C., Jacobs, I.J., Kaye, S.B., Kohn, E.C., Mills, G.B. and Urban, N.D. 10th biennial helene harris memorial trust meeting.
Cancer Res (2006) 66, 2904-2906.
Friedmann, B.J., Caplin, M., Savic, B., Shah, T., Lord, C.J., Ashworth, A., Hartley, J.A. and Hochhauser, D. Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Mol Cancer Ther (2006) 5, 209-218.
Gudmundsdottir, K. and Ashworth, A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.
Oncogene (2006) 25, 5864-5874.
Horsley, S.W., Mackay, A., Iravani, M., Fenwick, K., Valgeirsson, H., Dexter, T., Ashworth, A. and Kearney, L. Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes Chromosomes Cancer (2006) 45, 554-564.
Lord, C.J., Garrett, M.D. and Ashworth, A. Targeting the double-strand DNA break repair pathway as a therapeutic strategy.
Clin Cancer Res (2006) 12, 4463-4468.
McCabe, N., Turner, N.C., Lord, C.J., Kluzek, K., Bialkowska, A., Swift, S., Giavara, S., O'Connor M, J., Tutt, A.N., Zdzienicka, M.Z., Smith, G.C. and Ashworth, A. Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition.
Cancer Res (2006) 66, 8109-8115.
Sakamoto, K., Zarrinpashneh, E., Budas, G.R., Pouleur, A.C., Dutta, A., Prescott, A.R., Vanoverschelde, J.L., Ashworth, A., Jovanovic, A., Alessi, D.R. and Bertrand, L. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK{alpha}2 but not AMPK{alpha}1.
Am J Physiol Endocrinol Metab (2006) 290, E780-788.
McCabe, N., Lord, C.J., Tutt, A.N., Martin, N.M., Smith, G.C. and Ashworth, A. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
Cancer Biol Ther (2005) 4, 934-936.
Farmer, H., McCabe, N., Lord, C.J., Tutt, A.N., Johnson, D.A., Richardson, T.B., Santarosa, M., Dillon, K.J., Hickson, I., Knights, C., Martin, N.M., Jackson, S.P., Smith, G.C. and Ashworth, A. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature (2005) 434, 917-921.
Gudmundsdottir, K., Witt, E. and Ashworth, A. Roles of the BRCA1 and BRCA2 breast cancer susceptibility proteins in DNA repair.
In Balajee, A.S. (ed.), DNA Repair and Human Disease. Landes Bioscience, Georgetown, TX. (2005)
Gudmundsdottir, K., Lord, C.J., Witt, E., Tutt, A.N. and Ashworth, A. DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
EMBO Rep (2004) 5, 989-993.
Gudmundsdottir, K. and Ashworth, A. BRCA2 in meiosis: turning over a new leaf.
Trends Cell Biol (2004) 14, 401-404.
Arriola, E., Lambros, M.B., Jones, C., Dexter, T., Mackay, A., Tan, D.S., Tamber, N., Fenwick, K., Ashworth, A., Dowsett, M. and Reis-Filho, J.S. Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Lab Invest (2007) 87, 75-83.
Banerjee, S., Dowsett, M., Ashworth, A. and Martin, L.A. Mechanisms of disease:angiogenesis and the management of breast cancer.
Nat Clin Pract Oncol (2007) 4, 536-550.
Di Palma, S., Lambros, M.B., Savage, K., Jones, C., Mackay, A., Dexter, T., Iravani, M., Fenwick, K., Ashworth, A. and Reis-Filho, J.S. Oncocytic change in pleomorphic adenoma:molecular evidence in support of an origin in neoplastic cells.
J Clin Pathol (2007) 60, 492-499.
Johnson, N., Fletcher, O., Palles, C., Rudd, M., Webb, E., Sellick, G., dos Santos Silva, I., McCormack, V., Gibson, L., Fraser, A., Leonard, A.,
Gilham, C., Tavtigian, S.V., Ashworth, A., Houlston, R. and Peto, J. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Gilham, C., Tavtigian, S.V., Ashworth, A., Houlston, R. and Peto, J. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Hum Mol Genet (2007) 16, 1051-1057.
Jones, M.E., Folkerd, E.J., Doody, D.A., Iqbal, J., Dowsett, M., Ashworth, A. and Swerdlow, A.J.
Effect of delays in processing blood samples on measured endogenous
plasma sex hormone levels in women.
Effect of delays in processing blood samples on measured endogenous
plasma sex hormone levels in women.
Cancer Epidemiol Biomarkers Prev (2007) 16, 1136-1139.
Mackay, A., Urruticoechea, A., Dixon, J.M., Dexter, T., Fenwick, K., Ashworth, A., Drury, S., Larionov, A., Young, O., White, S., Miller, W.R.,
Evans, D.B. and Dowsett, M. Molecular response to aromatase inhibitor treatment in primary breast cancer.
Evans, D.B. and Dowsett, M. Molecular response to aromatase inhibitor treatment in primary breast cancer.
Breast Cancer Res (2007) 9, R37.
McCarthy, A., Savage, K., Gabriel, A., Naceur, C., Reis-Filho, J. and
Ashworth, A. A mouse model of basal-like breast carcinoma with metaplastic elements.
Ashworth, A. A mouse model of basal-like breast carcinoma with metaplastic elements.
J Pathol (2007) 211, 389-398.
Natrajan, R., Little, S.E., Sodha, N., Reis-Filho, J.S., Mackay, A., Fenwick, K., Ashworth, A., Perlman, E.J., Dome, J.S., Grundy, P.E., Pritchard-Jones, K. and Jones, C. Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour.
J Pathol (2007) 211, 52-59.
Natrajan, R., Williams, R.D., Grigoriadis, A., Mackay, A., Fenwick, K., Ashworth, A., Dome, J.S., Grundy, P.E., Pritchard-Jones, K. and Jones, C. Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.
Genes Chromosomes Cancer, (2007) 46, 607-615.
Pierga, J.Y., Reis-Filho, J.S., Cleator, S.J., Dexter, T., Mackay, A., Simpson, P., Fenwick, K., Iravani, M., Salter, J., Hills, M., Jones, C.,
Ashworth, A., Smith, I.E., Powles, T. and Dowsett, M. Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
Ashworth, A., Smith, I.E., Powles, T. and Dowsett, M. Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
Br J Cancer (2007) 96, 341-351.
Savage, K., Lambros, M.B., Robertson, D., Jones, R.L., Jones, C., Mackay, A., James, M., Hornick, J.L., Pereira, E.M., Milanezi, F., Fletcher, C.D.,
Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Caveolin 1 is overexpressed and amplified in a subset of basal like and metaplastic breast carcinomas: a morphologic, ultrastructural,i mmunohistochemical, and in situ hybridization analysis.
Schmitt, F.C., Ashworth, A. and Reis-Filho, J.S. Caveolin 1 is overexpressed and amplified in a subset of basal like and metaplastic breast carcinomas: a morphologic, ultrastructural,i mmunohistochemical, and in situ hybridization analysis.
Clin Cancer Res (2007) 13, 90-101.
Sleeman, K.E., Kendrick, H., Robertson, D., Isacke, C.M., Ashworth, A. and Smalley, M.J. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
J Cell Biol (2007) 176, 19-26.
Smalley, M.J., Iravani, M., Leao, M., Grigoriadis, A., Kendrick, H., Dexter, T., Fenwick, K., Regan, J., Britt, K., McDonald, S., Lord, C.J., Mackay, A.
and Ashworth, A. Regulator of Gprotein signalling 2 (RGS2) mRNA is differentially expressed in mammary epithelial subpopulations and overexpressed in the majority of breast cancers.
and Ashworth, A. Regulator of Gprotein signalling 2 (RGS2) mRNA is differentially expressed in mammary epithelial subpopulations and overexpressed in the majority of breast cancers.
Breast Cancer Res (2007) 9, R85.
Tischkowitz, M., Xia, B., Sabbaghian, N., Reis-Filho, J.S., Hamel, N., Li, G., van Beers, E.H., Li, L., Khalil, T., Quenneville, L.A., Omeroglu, A., Poll, A.,
Lepage, P., Wong, N., Nederlof, P.M.,Ashworth, A., Tonin, P.N., Narod, S.A., Livingston, D.M. and Foulkes, W.D. Analysis of PALB2/FANCN-associated breast cancer families.
Lepage, P., Wong, N., Nederlof, P.M.,Ashworth, A., Tonin, P.N., Narod, S.A., Livingston, D.M. and Foulkes, W.D. Analysis of PALB2/FANCN-associated breast cancer families.
Proc Natl Acad Sci U S A (2007) 104, 6788-6793.
Turner, N.C., Reis-Filho, J.S., Russell, A.M., Springall, R.J., Ryder, K., Steele, D., Savage, K., Gillett, C.E., Schmitt, F.C., Ashworth, A. and Tutt,
A.N. BRCA1 dysfunction in sporadic basal-like breast cancer.
A.N. BRCA1 dysfunction in sporadic basal-like breast cancer.
Oncogene (2007) 26, 2126-2132.
