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Exploiting the DNA repair defect in BRCA deficient cells as a therapeutic strategy; the use of PARP inhibitors
Investigating loss of DNA repair pathways in BRCA deficient cells as a synthetic lethal approach.
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The high-throughput identification of novel targets that confer synthetic lethality in BRCA mutant cells
Our work with PARP inhibitors has led us to attempt to identify in a high-throughput manner, further targets that confer synthetic lethality on BRCA deficient cells.
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The role and function of a BRCA2 binding protein, DSS1
Investigating the role and function of DSS1.
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The identification of novel BRCA2 synthetically lethal partners by the use of high-throughput RNA interference in Drosophila melanogaster
Identification of BRCA synthetically lethal partners using RNAi screens in the fruit fly Drosophila melanogaster.
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Identification of novel determinants of Tamoxifen resistance
Investigating loss of DNA repair pathways in BRCA deficient cells as a synthetic lethal approach.
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PNKP as a novel therapeutic target
High-throughput identification of small molecule inhibitors of PNKP that may be synthetically lethal in BRCA deficient cells.
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The development of an inhibitor of the phosphatase PPM1D
Identification of compounds that can kill tumour cells by inhibiting PPM1D.
