Publications
Bavetsias, V., Sun, C., Bouloc, N., Reynisson, J., Workman, P., Linardopoulos, S. and McDonald, E. Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.
Bioorg Med Chem Lett (2007) 17, 6567-6571.
Briassouli, P., Chan, F., Savage, K., Reis-Filho, J.S. and Linardopoulos, S. Aurora-A Regulation of Nuclear Factor-{kappa}B Signaling by Phosphorylation of I{kappa}B{alpha}
Cancer Res (2007) 67, 1689-1695.
Linardopoulos, S. Aurora-A kinase regulates NF-kappaB activity: lessons from combination studies.
J Buon (2007) 12 Suppl 1, S67-70.
Rayter, S., Elliott, R., Travers, J., Rowlands, M.G., Richardson, T.B., Boxall, K., Jones, K., Linardopoulos, S., Workman, P., Aherne, W., Lord, C.J. and Ashworth, A. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
Oncogene. (2007)
Chan F, Sun C., Perumal M., Nguyen Q-D., Bavetsias V., McDonald E., Martins V., Wilsher N.E., Raynaud F.I., Valenti M, Eccles S., te Poele R., Workman P, Aboagye E.O. and Linardopoulos S. Mechanism of Action of the Aurora Kinase Inhibitor CCT129202 and In vivo Quantification of Biological Activity.
Mol Cancer Ther (2007) 6: 3147-3157
Sun C., Chan F., Briassouli P., Linardopoulos S. Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents.
Biochem Biophys Res Commun. (2007) 352(1): 220-225.
Whittaker SR, te Poele RH, Chan F, Linardopoulos S, Walton MI, Garrett MD and Workman P. The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis.
Cell Cycle (2007) 6: 3114 - 3131
Briassouli P, Chan F, Savage K, Reis-Filho JS and Linardopoulos S. Aurora- A regulation of NF-κB signalling via IκBα ubiquitination.
Cancer Res (2007) 15: 1689-1695
Briassouli, P., Chan, F. and Linardopoulos, S. The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I{kappa}B{alpha}.
Human Molecular Genetics (2006) 15(22): 3343-50
Chieffi P, Cozzolino L, Kisslinger A, Libertini S, Staibano S, Mansueto G, De Rosa G, Villacci A, Vitale M, Linardopoulos S, Portella G and Tramontano D. Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation
Prostate (2006) 66: 326-333
Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A and Portella G. Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
J Clin Endocrinol Metab (2005) 90(2):928-935
Sun C, Newbatt Y, Douglas L, Workman P, Aherne W and Linardopoulos S. High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase.
J. Biomol. Screening (2004) 9(5):391-397
Chieffi P, Troncone G, Caleo A, Libertini S, Linardopoulos S, Tramontano D and Portella G. Aurora B expression in normal testis and seminomas.
Journal of Endocrinology (2004) 181(2):263-270
