Publications
Chan F, Sun C., Perumal M., Nguyen Q-D., Bavetsias V., McDonald E., Martins V., Wilsher N.E., Raynaud F.I., Valenti M, Eccles S., te Poele R., Workman P, Aboagye E.O. and Linardopoulos S. Mechanism of Action of the Aurora Kinase Inhibitor CCT129202 and In vivo Quantification of Biological Activity.
Mol Cancer Ther (2007) 6: 3147-3157
Sun C., Chan F., Briassouli P., Linardopoulos S. Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents.
Biochem Biophys Res Commun. (2007) 352(1): 220-225.
Briassouli P, Chan F, Savage K, Reis-Filho JS and Linardopoulos S. Aurora- A regulation of NF-κB signalling via IκBα ubiquitination.
Cancer Res (2007) 15: 1689-1695
Briassouli, P., Chan, F. and Linardopoulos, S. The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I{kappa}B{alpha}.
Human Molecular Genetics (2006) 15(22): 3343-50
Sun C, Newbatt Y, Douglas L, Workman P, Aherne W and Linardopoulos S. High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase.
J. Biomol. Screening (2004) 9(5):391-397
Ewart-Toland, A., Briassouli, P., de Koning, J.P., Mao, J-H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B.A.J., Nagase, H., Burns, J., West, S., Linardopoulos, S. and Balmain, A. Identification of Aurora2/STK6/STK15 as a candidate low penetrance tumor susceptibility gene in mouse and man.
Nat Genet (2003) 34, 403-412
