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Projects

Drug Target Discovery Projects

We aim to further understand mitotic control and use this information to identify and validate mitotic regulators as targets for cancer therapy.

  • Association of Aurora-A with p53/Fbxw7, characterisation and validation of Aurora-A mutants
    Studying the association of Aurora-A and p53/Fbxw7 in breast cancer using cellular and in vivo models and validating the Aurora-A mutants in tumour development.
  • Investigation of Mps1 involvement in the mitotic checkpoint
    Identifying the molecular mechanisms of mitotic checkpoint regulation by Mps1.
  • Development of Aurora A and Mps1 inhibitors
    Developing cancer drug screens for cell cycle pathway targets with oncogenic activity.
  • New targets
    Identifying genes that, when silenced, cause ploidy-specific lethality and validating them as new targets towards aneuploidy in cancer.

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