Publications

Killock DJ, Parsons M, Zarrouk M, Ameer-Beg SM, Ridley AJ, Haskard DO, Zvelebil M, Ivetic A. In vitro and in vivo characterization of molecular interactions between calmodulin, ezrin/radixin/moesin (ERM) and L-selectin.

J Biol Chem. (2009) Jan 7.

Hoffman H. E, Jiraskova J, Ingr M., Zvelebil M., & Konvalinka J. Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.

Protein Expr Purif (2009) 63, 62 - 67

Zvelebil, M. J., Waterfield, M. D., & Shuttleworth, S. J. Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors.

Arch Biochem Biophys (2008) 477, 404-10

Chris Richardson, Q. G., Costas Mitsopoulous, Marketa Zvelebil, Laurence Pearl, Frances Pearl MoKCa Database - Mutations of Kinases in Cancer

Nucl. Acids Res (2008) gkn832

Reynolds, C. H., Garwood, C. J., Wray, S., Price, C., Kellie, S., Perera, T., Zvelebil, M., Yang, A., Sheppard, P. W., Varndell, I. M., Hanger, D. P., & Anderton, B. H. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.

J Biol Chem (2008) 283, 18177-86

Datta, S. R., McQuillin, A., Rizig, M., Blaveri, E., Thirumalai, S., Kalsi, G., Lawrence, J., Bass, N. J., Puri, V., Choudhury, K., Pimm, J., Crombie, C., Fraser, G., Walker, N., Curtis, D., Zvelebil, M., Pereira, A., Kandaswamy, R., St Clair, D., & Gurling, H. M. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia.

Mol Psychiatry (2008) Dec 2

Ditzel, M., Broemer, M., Tenev, T., Bolduc, C., Lee, T. V., Rigbolt, K. T., Elliott, R., Zvelebil, M., Blagoev, B., Bergmann, A., & Meier, P. Inactivation of effector caspases through nondegradative polyubiquitylation.

Mol Cell (2008) 32, 540 - 553

Folkes, A. J. et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.

J Med Chem (2008) 51, 5522 - 5532

Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J., & Meier, P. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

Nat Cell Biol (2008) 10, 1309 - 1317

Kendrick, H., Regan, J. L., Magnay, F. A., Grigoriadis, A., Mitsopoulos, C., Zvelebil, M., & Smalley, M. J. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.

BMC Genomics (2008) 9, 591

Zvelebil MJ & Baum JO Understanding Bioinformatics (book)

Garland Publishing Inc,US; (2007) ISBN 0815340249.

Gharbi SI, Zvelebil MJ, Shuttleworth SJ, Hancox T, Saghir N, Timms JF, Waterfield MD. Exploring the specificity of the PI3K family inhibitor LY294002.

Biochem J. (2007) 404, 15-21.

Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Science (2007) 13, 239-242.

Seoighe C, Ketwaroo F, Pillay V, Scheffler K, Wood N, Duffet R, Zvelebil M, Martinson N, McIntyre J, Morris L and Hide W. A model of directional selection applied to the evolution of drug resistance in HIV-1

Molecular Biology and Evolution (2007) 24, 1025-1031.

Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman J, Akpan A, Yang A, Zvelebil M, Cramer R, Stimson L, Aherne W, Banerji U, Judson I, Sharp S, Powers M, deBilly E, Salmons J, Walton M, Burlingame A, Waterfield M and Workman P. Gene and protein expression profiling of human ovarian cancer cells treated with the HSP90 inhibitor 17-allylamino-17-demethoxy geldanamycin (17AAG)

Cancer Research (2007) 67, 3239-53.

Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T & Lu X. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53.

Nature Genetics (2006) 38: 1133-1141

Sims D, Bursteinas B, Gao Q, Zvelebil M, Baum B. FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets.

N.A.R (2006) 34, D479-D483.

Ng A. Bursteinas B. Gao Q. Mollison E. and Zvelebil M. Resources for integrative systems biology: From data through databases to networks and dynamic system models.

Briefings in Bioinformatics (2006) 7, 318-330.

Ng A, Bursteinas B, Gao Q, Mollison E, Zvelebil M. pSTIING: a ‘systems’ approach towards integrating signalling pathways, interaction and transcriptional regulatory networks in inflammation and cancer.

N.A.R (2006)34, D527-D534.

Williams, J.G. and Zvelebil, M. SH2 domains in plants.

Trends in Plant Science (2004) 9,161-163.

Zhukovskaya, N.V., Fukuzawa, M., Tsujioka, M., Jermyn, K.A., Kawata, T., Zvelebil, M. and Williams, J.G. Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.

Development (2004) 131, 447-458.

Nagano K, Masters JR, Akpan A, Yang A, Corless S, Wood C, Hastie C, Zvelebil M, Cramer R, Naaby-Hansen S Differential protein synthesis and expression levels in normal and neoplastic human prostate cells and their regulation by type I and II interferons.

Oncogene (2004) 23, 1693-703.