Gyrd-Hansen M.*, Darding M.*, Miasari M., Tenev T., da Fonseca P., Zvelebil M., Bujnicki J., Silke J., Santoro M.M., Lowe S, and Meier P. (*) equal contribution. IAPs Carry an evolutionarily conserved ubiquitin-binding domain that is indispensable for NF-kB regulation as well as cell survival and oncogenesis.
Nat Cell Biol. (11),1309-17. 2008
Ditzel M.*, Broemer M.*, Tenev T., Bolduc C., Elliott R., Zvelebil M., Bergmann A. and Meier P. (*) equal contribution. Inactivation of effector caspases through non-degradative polyubiquitylation.
Mol Cell. (4), 540-553. 2008
Lhocine N.*, Ribeiro P.S.*, Buchon N., Wepf A., Wilson R., Tenev T., Lemaitre B., Gstaiger M.$, Meier P$, Leulier F$. PIMS modulates immune tolerance by negatively regulating the Drosophila Imd pathway.
Cell Host & Microbes. (4), 147-158. 2008
Ribeiro P., Kuranaga E., Tenev T., Leulier, F., Miura M., and Meier P. DIAP2 functions as a ‘mechanism-based’ regulator of drICE that contributes to the caspase activity threshold in living cells.
J Cell Biol. (7):1467-1480. 2007
Tenev, T., Ditzel, M., Zachariou, A. and Meier, P. The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.
Cell Death Differ 14(10):1191-201 (2007)
Meier P and Vousden KH. Lucifer’s Labyrinth – Ten Years of Pathfinding in Cell Death.
Mol. Cell. Dec 14;28(5):746-54, 2007.
Ribeiro PS, Kuranaga E, Tenev T, Leulier F, Miura M, Meier P. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
J Cell Biol. Dec 31;179(7):1467-80, 2007.
Leulier, F, Lhocine, N, Lemaitre, B and P. Meier. The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection.
Mol Cell Biol 26: 7821-31; 2006
Leulier F., Ribeiro PS., Palmer E., Tenev T., Takahashi K., Robertson D., Zachariou A., Pichaud F., Ueda R. and P. Meier. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.
Cell Death & Diff. 1-12; 2006.
Ditzel M. and P. Meier. Ubiquitylation in apoptosis: DIAP’s (N-)en(d)igma.
Cell Death & Diff. 12: 1208-1212; 2005.
Tenev T., A. Zachariou, R. Wilson, M. Ditzel and P. Meier. IAPs are functionally non-equivalent and regulate effector-caspases through distinct mechanisms.
Nat Cell Biol 7(1): 70-77; 2005.
Ditzel M., R. Wilson, T. Tenev, A. Zachariou, A. Paul, E. Deas and P. Meier. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
Nat Cell Biol 5, 467-73; 2003.
Meier, P. and J. Silke. Programmed cell death: Superman meets Dr Death.
Nat Cell Biol 5(12): 1035-8; 2003.
Zachariou, A., T. Tenev, L. Goyal, J. Agapite, H. Steller and P. Meier. 22 IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding.
EMBO J (24): 6642-52; 2003.
Ditzel M and P. Meier. Apoptosis: More than Meets the Eye.
Cell 111, 465-467; 2002
Wilson R., L. Goyal, M. Ditzel, A. Zachariou, D.A. Baker, J. Agapite, H. Steller and P. Meier. The DIAP1 RING finger mediates ubiqitination of Dronc and is indispensable for regulating apoptosis.
Nat Cell Biol 4, 445-450; 2002.
Ditzel M and P. Meier. IAP degradation: decisive blow or altruistic sacrifice?
TRENDS in Cell Biology Vol. 12, No. 10, October; 2002.
Tenev T., A. Zachariou, R. Wilson, A. Paul and P. Meier. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1
EMBO J Vol. 21. No. 19, 5118-5129; 2002.