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Apoptosis Projects

"Our research focuses on how cancer cells bypass apoptosis and survive and propagate inappropriately."

  • IAPs as Ub-receptors in Ub-dependent survival signalling
  • Ub-mediated regulation of caspases
    Investigating the molecular mechanism through which IAPs block caspases
  • Linking microbial infections to chronic inflammation and cancer.
  • Ubiquitin-mediated regulation of apoptosis
    Studying the mechanism of how the Ub conjugation and deconjugation system impacts on cell survival.
  • Systematic analysis of putative components of the Drosophila cell death machinery and innate immune response.
    Identifying new cell death regulators.
  • Overcoming the anti-apoptotic threshold
    Investigating IAP-binding proteins to identify novel IAP-regulatory proteins.

See also

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